The main effect of zoledronic acid is to inhibit bone resorption. Side effects of zoledronic acid include fever, flu-like symptoms, and myalgia. Zoledronic acid belongs to oxygenated bisphosphonic acid compounds, which mainly act on human bones and inhibit bone resorption through the inhibition of osteoclasts. The commonly used dosage forms of zoledronic acid are zoledronic acid for injection and zoledronic acid injection. Zoledronic acid for injection is mainly used for bone pain caused by osteolytic bone metastases of malignant tumors. Zoledronic acid for injection is mainly used for osteoporosis in postmenopausal women, osteoporosis in adult men to increase bone mass, and for the treatment of Paget’s disease (metaplastic osteitis). The most common side effect of zoledronic acid is fever; other common side effects are flu-like symptoms, myalgia, arthralgia, headache, dizziness, nausea, vomiting, and diarrhea. In addition, zoledronic acid is contraindicated in patients who are allergic to zoledronic acid or other bisphosphonates, pregnant and lactating women, patients with severe renal insufficiency, and patients suffering from acute gastrointestinal inflammation. If you need to use zoledronic acid, it is recommended that you consult a professional doctor and follow the doctor’s instructions to regulate the use of medication.