At present, with the development of medicine, there are more and more types of immunosuppressants and diversified combinations, and there are differences in medical knowledge and experience among physicians in each kidney transplantation center, therefore, there are differences in immunosuppressants for each patient. Will my medication be worse than others? These questions will affect the patient’s psychology, worry and concern always accompany the patient’s mind. According to the current medical knowledge and research progress of kidney transplantation, there is no one best solution, because each drug has its unique side effects, and these side effects are unforeseeable in the population. Therefore, the side effects of a drug can only be detected based on each after use. And different immunosuppressants are also chosen due to the different underlying conditions of each individual. A brief description of common immunosuppressant side effects. Cyclosporine: It has been used for the longest time, mainly for gum enlargement, hirsutism, high blood lipids, and dark face. So many beauty lovers and handsome men can not tolerate these side effects, as well as nephrotoxicity, immunosuppression intensity – medium. Tacrolimus (FK506): mainly hyperglycemia, hand tremor, insomnia, hair loss, nephrotoxicity, immunosuppression intensity – strong. Rapamycin: mainly hyperlipidemia, proteinuria, immunosuppression intensity – moderate. Primulis: mainly infection, leukopenia, bone marrow suppression, immunosuppression intensity – strong. Imipramine: mainly infection, bone marrow suppression, and also elevated uric acid, immunosuppression intensity – medium. Prednisone: infections, osteoporosis, hyperglycemia, etc. Therefore, the immunosuppressive strength and drug toxicity needed by the patient should be fully considered when choosing immunosuppressive drugs in each patient. For example, a relative with a better kidney transplant mating needs a low intensity of immunosuppression, and if drug nephrotoxicity occurs, consider switching cyclosporine and tacrolimus for rapamycin. Some recipients with high risk factors for rejection, such as second kidney transplantation, patients with multiple previous acute rejection reactions, and patients with postoperative humoral rejection, may consider applying the combination of tacrolimus + primaquine + prednisone. In the case of diabetic recipients who require insulin injections, the use of Tacrolimus may aggravate the diabetic condition and affect the long-term prognosis of the patient. Therefore. In this group of patients, cyclosporine + primidone + prednisone may be considered if there are no high-risk factors for rejection. For some recipients at high risk of infection, such as patients with advanced age, underlying lung lesions, and low lymphocyte counts, a combination of immunosuppressive agents with a weaker immunosuppressive intensity, such as tacrolimus/cyclosporine + imipramine, may be used, and then readjusted when immunity is restored. Therefore, the combination and choice of immunosuppressive agents is not uniform and needs to be analyzed on a patient-by-patient basis. Different people choose different regimens. Just like shoes are good to wear wife is good only you know. Therefore, doctors will consider the above situation when choosing immunosuppressants, and do not need to compare with kidney friends. Emphasis on one point: transplanted kidney biopsy is particularly important for choosing the right immunosuppressive regimen, and adjusting the immunosuppressive regimen according to the pathological results is important to improve the long-term survival of the transplanted kidney.