Some statistics have found that 38.5% of women and 17.9% of men have diabetes combined with cholelithiasis, while the incidence of cholelithiasis in non-diabetics is 21.7% for women and 8.7% for men. Diabetic patients are prone to gallstone disease, probably due to the fact that diabetic patients are often associated with hypercholesterolemia and are prone to gallstones. In addition, diabetes is easily accompanied by neuropathy, making the gallbladder motor dysfunction, large and flaccid empty gallbladder, easy to form gallstones. Since diabetic patients with gallstones are prone to become critically ill within a short period of time once acute inflammation is complicated, and the mortality rate is as high as 22% when emergency surgery is performed, and the postoperative complication rate is also high (51%), patients with diabetes combined with gallstone disease, whether symptomatic or not, should receive laparoscopic or surgical treatment as early as possible to prevent these dangerous situations.