Follicular development is regulated by the hormones secreted by the reproductive axis, that is, by the hormones secreted by the hypothalamus and pituitary gland, which are mainly affected by hypothalamic factors, pituitary lesions and ovarian lesions: 1. 2, pituitary lesions: for example, the most common is pituitary microadenoma, it will lead to increased levels of prolactin, and finally lead to poor follicle development; 3, ovarian lesions: such as polycystic ovary syndrome, ovarian chocolate cysts, ovarian insufficiency, premature ovarian failure, can lead to poor follicle development; 4, hormones: menstruation is also affected by the hormones secreted by the thyroid and adrenal glands, if If the thyroid function and adrenal function are abnormal, it can also lead to poor follicle development.