The fundamental difference between chickenpox and hives is the cause. The cause of chickenpox is a virus, which can cause a series of symptoms and multiply in the body after infection, and can be transmitted to other people through respiratory droplets, so chickenpox can be contagious. After having chickenpox or being vaccinated against chickenpox, a person can acquire the corresponding immunity and will not get chickenpox again in the future. However, the cause of hives is not a virus or any other pathogen that can cause infections in the human body. There is no pathogen, it is simply an allergic reaction caused by an abnormality in the body’s immune system. Therefore, hives can not be vaccinated or other means to obtain the corresponding ability not to hives. In addition, chickenpox and urticaria also have a very big difference in symptoms, both can have itching, but the chickenpox rash is polymorphic papules, herpes, scabs can be seen at the same time. And the rash of urticaria is mainly in one form, either in the form of papules or in the state of a furuncle.