The cause of pain in the big toe may be osteoarthritis, gout or bunion. General treatment, physiotherapy, medication and surgery should be given to address the cause of the pain. 1. If osteoarthritis is the cause of the pain, avoid strenuous exercise, you can take oral anti-osteoporosis drugs, such as bone fairy tablets or anti-osteoporosis pills, severe pain can be oral non-steroidal painkillers, such as ibuprofen extended-release capsules, you can take ultrasound physiotherapy, if conservative ineffective to take the joint cleaning surgery. 2. If the gout is caused by gout, you need to apply ice packs, reduce purine food intake, and apply uric acid-lowering drugs such as febuxostat. 3. If the bunion is caused by orthopedic braces, topical diclofenac diethylamide cream can be used. In severe cases, orthopedic surgery is needed. It is recommended to go to the hospital for medical examination, to clarify the cause of the disease for further treatment, do not blindly use drugs.