The difference between vulvar leukoplakia and eczema lies in the differences in the causes of the disease and the manifestation of symptoms, such as the differences in skin color and skin morphology. Vulvar leukoplakia is caused by chronic inflammatory stimulation of the vulva, endocrine disorders, heredity and so on. Vulvar leukoplakia is characterized by localized whitening of the vulva, decreased skin elasticity, which can cause vulvar atrophy and pain or itching. Vulvar eczema may be caused by allergy or localized impurity. Vulvar eczema in the acute stage usually has erythema, edema, blisters and other manifestations, blisters rupture can lead to localized vesicles, oozing, etc., in the chronic stage can appear skin thickening, peeling and other manifestations, which can be accompanied by hyperpigmentation and itching and so on. The difference between vulvar leukoplakia and eczema also lies in the different treatments. If patients have vulvar leukoplakia or vulvar eczema, it is recommended that they should consult a doctor in time, and under the guidance of the doctor, complete the relevant examinations to clarify the cause of the disease and then treat the symptoms.