IVF down-regulation is a treatment to regulate hormone levels in the body through the use of relevant drugs to promote ovulation and help pregnancy. The main purpose of down-regulation in IVF is to inhibit the pituitary gland’s self-regulation, promote the secretion of gonadotropins, avoid spontaneous ovulation, and promote multiple ovulation to synchronize the development of multiple eggs to increase the chances of conception, etc. The main ingredients of the drugs are gonadotropin-releasing hormone agonists. The main ingredient of down-regulation drugs is gonadotropin-releasing hormone agonist, and the drug itself may have side effects. Some patients may experience nausea, vomiting, weight gain, and skin allergic reactions, such as hives, rashes, and itching after down-regulation treatment, and a very small number of patients may experience edema, vaginal bleeding, and emotional instability. It is recommended that pregnant women actively cooperate with the doctor’s treatment, and at the same time pay attention to observe their own conditions, so if the adverse reactions continue to worsen or long time can not be relieved should promptly consult a doctor.