People with chickenpox often have fever and itchy blisters. Many patients require supportive therapy to manage these symptoms, such as itch relief, nail clipping, and fever reduction. The initiation of antiviral therapy depends on the patient’s age, the presence of coexisting conditions, and the patient’s clinical presentation. Although chickenpox is often self-limiting, complications can be life-threatening. The following general measures can be used for symptomatic management of the rash and fever, and can also help reduce the risk of certain complications: 1. Antihistamines help in the symptomatic management of itching, such as cetirizine and loratadine. 2. Nails should be kept as short as possible to avoid scratching that can cause significant skin breakdown and secondary bacterial infection. 3. Acetaminophen should be given to treat fever, especially in children. Oral therapy, such as valaciclovir or acyclovir, may be given to immunocompetent individuals without evidence of complications. Oral medications are well tolerated and serious side effects are rare. For most other patients, acyclovir can be given intravenously rather than orally, due to the superior bioavailability of intravenous administration compared to oral administration and the fact that intravenous administration has been widely used to treat immunocompromised hosts. If you have chickenpox, you should visit a hospital promptly to avoid delays.