Yingtaiqing that diclofenac sodium, diclofenac sodium and celecoxib which pain can not be generalized, both can play a role in pain, but the two in the pharmacological effects, indications, adverse reactions and other aspects of the differences, can not directly determine which drug pain effect. 1. Pharmacological effects: diclofenac and celecoxib are non-steroidal anti-inflammatory drugs, but diclofenac sodium is a non-selective cyclo-oxygenase inhibitor, and celecoxib is a selective cyclo-oxygenase-2 inhibitor, so celecoxib selective, adverse drug reactions are relatively light. 2. Indications: Celecoxib is indicated for acute pain, osteoarthritis and rheumatoid arthritis in adults, while diclofenac sodium is indicated for acute attacks of gout, rheumatoid arthritis, ankylosing spondylitis and other inflammatory and degenerative diseases, bursitis, tenosynovitis and other non-articular soft tissue rheumatism pain. 3. Adverse reactions: diclofenac sodium common adverse drug reactions include headache, dizziness, vertigo, nausea, diarrhea, etc., celecoxib common adverse drug reactions for rash, sinusitis and upper respiratory tract infection. Both need to be used with care not to be combined with other NSAIDs, and to minimize the duration and dose of use. Diclofenac and celecoxib should be used under the guidance of a physician, and it is recommended that patients go to the relevant departments of regular hospitals to consult in detail and follow the doctor’s instructions.