Esophageal cancer t3n0m0 is not particularly serious, and its prognosis is better if it receives timely surgical treatment, or more serious if the disease progresses. Esophageal cancer t3n0m0 refers to the malignant tumor of esophagus with tumor cells infiltrating into the outer membrane of esophagus, without regional lymph node metastasis and distant metastasis. If patients with this stage of esophageal cancer receive timely surgical treatment with appropriate postoperative chemotherapy, the prognosis is relatively good, but it should be noted that patients should undergo regular review. If the patient’s physical condition cannot tolerate surgery, then chemotherapy or targeted drug therapy should be considered. In conclusion, patients with esophageal cancer in t3n0m0 stage can maintain a positive mindset, undergo surgery if they can tolerate surgery, actively cooperate with doctors for postoperative chemotherapy and other treatments, and undergo regular review, they can often get better curative effect and prognosis.