Fissures in the penile skin are usually caused by inflammation, and it is the more serious inflammation that causes fissures in the penile skin, while ordinary foreskin glansitis does not cause fissures in the penile skin. The main clinical cause is severe Candida glans, the penis skin will appear fissured with a milky discharge, the patient will also be accompanied by itching and burning sensation. There are also some patients who have penile skin fissures caused by diabetes, which are small vertical rows of fissures, and in severe cases, they are accompanied by the inability to turn up the glans foreskin, and the pain is very obvious. The specific medication for penile foreskin fissure can be selective according to the patient’s specific condition, such as Candida glansitis patients can use clotrimazole cream for external application, while diabetes-induced penile fissure in addition to active control of blood sugar can be used to rehabilitate the new liquid for external washing, the specific cause and specific medication should be decided by the doctor.