Di-George syndrome, or Di-George syndrome, is a primary cellular immunodeficiency disorder. Children with this disease are born without or with underdeveloped thymus and parathyroid glands, and are often accompanied by other congenital malformations such as cardiac macrovascular malformations. Because of the defective immune cells, they are susceptible to severe viral, fungal and Pneumocystis carinii infections, and can have severe reactions to live attenuated vaccines. The main treatment is to strengthen nursing care and enhance nutrition to improve the immunity of the children; avoid contact with infected patients to prevent infection; avoid vaccination; once infection occurs, it should be treated as soon as possible; due to parathyroid insufficiency, hypocalcemia is easy to occur, so it is necessary to pay attention to calcium supplementation; thymic peptide, interferon and other infusions to regulate the immune system; bone marrow transplantation and thymus transplantation are the more desirable treatment options.