Waking up at 2 o’clock in the middle of the night is mostly caused by the presence of mental and psychological factors, such as the patient being nervous or stressed, and there are things that bother the patient, and after waking up at 2 o’clock in the middle of the night, it may be difficult to sleep because of thinking about these things. It is recommended that patients take this natural treatment, do not just take drugs to interfere with the process of sleep, patients can adjust their mindset. There are also more physical activities during the day to make the body more robust, so that the body is in a state of fatigue, the depth of sleep at night has improved, may not wake up at 2:00 in the middle of the night. And after adjusting themselves, still wake up at 2:00 in the middle of the night can not sleep, in this case it is recommended that patients can take oral dexrazoxane, diazepam, eszopiclone this kind of drugs to improve sleep.