Toothache and fever are mainly caused by periodontal disease, endodontic disease or wisdom tooth pericoronitis; it is recommended to consult a doctor for symptomatic treatment, and the above symptoms cannot be cured by themselves. 1. Periodontal disease: acute periodontal abscess or acute gingival papillitis is more serious, and inflammatory substances are easy to spread into the blood system and cause fever and chills. It is necessary to carry out abscess incision and drainage and periodontal irrigation treatment, and take anti-inflammatory drugs (such as amoxicillin, metronidazole, etc.) under the guidance of the doctor in order to effectively control the inflammation. 2. Endodontic disease: pulpitis or periapical inflammation, if not treated in time, can also lead to aggravation of symptoms and cause fever and chills and other immune reactions; root canal treatment is required to clean up the necrotic and inflamed nerves and inflammatory substances, and anti-inflammatory medications must be taken as mentioned above. 3. Wisdom tooth pericoronitis: inflammation and suppuration of the gums around the wisdom tooth will also spread to the maxillofacial space leading to interstitial infections, which in turn will cause systemic fever and other stress reactions; the pericoronary rinsing of the medication and drugs (the specific drugs are the same as the above) anti-inflammatory and anti-inflammatory treatment in order to effectively control the infection and fever and other symptoms. It is recommended to actively seek medical advice and follow the doctor’s instructions for medication and treatment.