Non-specific cutaneous peripheral T-cell lymphoma is a kind of non-Hodgkin’s lymphoma, which mainly originates from post-thymic T-cells and NK-cells, and belongs to malignant tumors, with fever, night sweats, emaciation and itching of the skin as the main symptoms, and its pathogenesis is mainly related to infections and immune factors. 1. Infection: Some studies have shown that EBV infection is a predisposing factor for peripheral T-cell lymphoma. After infected with EBV, because the body strictly limits the proliferation of virus particles, in most cases, the dynamic balance between the two is maintained, and the infected person carries the virus for a lifetime but does not develop the disease; when the balance between the immune function of the body and the EBV is damaged, it may lead to the occurrence of peripheral T-cell lymphoma. 2. Immunity: low immune function is related to the development of non-specific cutaneous peripheral t-cell lymphoma, patients with hereditary or acquired immunodeficiency have more non-specific cutaneous peripheral t-cell lymphoma than normal people, and long-term application of immunosuppressant after organ transplantation can also lead to the increased incidence of non-specific cutaneous peripheral t-cell lymphoma. The development of non-specific cutaneous peripheral t-cell lymphoma is the result of a combination of factors, but also related to genetics, physical and chemical factors, etc. Patients should go to the hospital in a timely manner to consult the doctor, and follow the doctor’s instructions for chemotherapy, hematopoietic stem cell transplantation and other treatments, to help patients to improve their symptoms and prognosis.