The soles of the feet peeling due to various reasons caused by the epidermal layer of keratinization abnormalities caused by the common causes of chronic eczema, tinea pedis, contact dermatitis, etc., according to the different diseases, can be used to anti-inflammatory anti-itch, anti-fungal, anti-allergy and other ways to solve. 1. Chronic eczema: chronic inflammatory reaction of the skin, can be used externally with corticosteroids, such as halometasone, trimethoprim, etc., oral antihistamine such as loratadine. 2. Tinea pedis: positive fungal test can be diagnosed, and can be treated with topical azole or acrylamide drugs, such as terbinafine and econazole. If necessary, oral itraconazole and other drugs. 3. Contact dermatitis: local erythema and flaking caused by local contact with irritating or allergic substances, it is necessary to pay attention to avoid re-exposure to the same substances, and can be treated with topical mometasone furoate cream, oral loratadine anti-allergy treatment, and at the same time, pay attention to moisturizing care, such as the use of vitamin E milk. If the soles of the feet peeling, it is recommended that the hospital, after the condition is clear, to take targeted treatment, the above drugs need to follow the doctor’s instructions.