Papular urticaria is a skin disease in which a person has an allergic reaction such as papular blistering and itching of the skin due to insect bites. The typical symptom of this disease is the appearance of skin papules, which is also the origin of the name of this disease. In fact, the main cause of papular urticaria is an allergic reaction to the skin caused by insect bites, which mostly manifests as scattered or clustered papular clusters that grow on various parts of the body, especially on the extremities and trunk. The bumps are usually about the size of soybeans or peanuts, with small blisters growing on top, which will spread after scratching and become large blisters without redness of the surrounding skin. At the same time, the patient will experience itching symptoms due to the reaction to the insect venom and may even have difficulty sleeping due to the intense itching sensation in the affected area. If scratching cannot be controlled, resulting in breakage of the papules, subsequent infection may occur. However, other than papular skin growth and itching, there are usually no other abnormal symptoms of a systemic nature. Papular urticaria mostly occurs in infants and young children and has a greater impact on normal life and can be treated with medication. The use of antihistamines is generally effective, supplemented by glyburide lotion to help relieve the itchiness of the affected area. The most obvious symptom of papular urticaria is the appearance of papules or blisters on the skin, which are mostly the size of soybeans and accompanied by a more intense itching sensation, and can be treated with antihistamines.