Many hypertensive patients have this idea: they have been using one type of antihypertensive drug for many years, should they change to another type of antihypertensive drug? If you take the same antihypertensive drug for a long time, will it produce drug resistance? In fact, as long as the antihypertensive drugs currently being taken can control blood pressure well up to standard, and no adverse reactions occur, there is no need to change antihypertensive drugs, and there is no such thing as drug resistance. Usually, most of the side effects of antihypertensive drugs occur a few days or weeks after the drug is first started. If no adverse reactions occur after a long time, it means that the antihypertensive drugs are well tolerated and there is no need to worry about the side effects of using a drug for a long time, and there is no need to change the drug. However, certain indicators need to be monitored regularly, such as long-term use of diuretics, need to pay attention to monitor the blood electrolyte disorders; long-term use of calcium antagonists, need to pay attention to the presence of edema, gingival hyperplasia, etc.. The goal of antihypertensive treatment should be long-term, lasting and smooth control of blood pressure in order to reduce the adverse effects of hypertension on the human body. Frequent changes in antihypertensive drugs without obvious reasons can lead to fluctuations in blood pressure, which can have adverse effects on the heart, brain and kidneys. Currently most of the commonly used antihypertensive drugs are medium and long-acting antihypertensive drugs, some of which take more than 1 week to reach a steady state of concentration in the blood and play a lasting and stable antihypertensive effect, so you can’t be too anxious and need to monitor blood pressure dynamically. Some patients who started taking a certain antihypertensive drug have good blood pressure control, but after a few years the blood pressure increased again, they think that the original drug “resistant”, in fact, this is a wrong idea, this is not “resistant”, but their own blood pressure is higher than the original The reason for this is related to ageing and atherosclerosis. This time, you need to adjust your medication under the guidance of a regular hospital cardiologist.