When to reduce and stop medication is a great concern for patients from the beginning of treatment and a very difficult question for clinicians to answer. Available evidence shows that 70-80% of patients with epilepsy can have their seizures controlled with medication, and more than 60% of these patients remain seizure-free after medication is withdrawn. Within 2 years of starting a medication reduction, approximately 30% of patients may have a seizure reoccurrence, with the vast majority of seizures occurring within the first 9 months of starting a medication reduction. 1. Patients who have been completely seizure-free for more than 2-5 years on medication may be considered for discontinuation. 2. Patients who have been seizure-free for a longer period of time are still at risk of having another seizure after discontinuation of medication and should be evaluated for the possibility of having another seizure before deciding whether to discontinue medication. Patients with consistently abnormal EEG, multiple seizure types, significant neuroimaging abnormalities and neurological deficits have a significantly higher recurrence rate and should be on medication for a longer period of time. 3. Different syndromes have different prognosis, which directly affects the long-term remission rate after drug discontinuation. For example, in benign epilepsy syndromes in children, 1-2 years without seizures can be considered for drug discontinuation; in adolescent myoclonic epilepsy, even after 5 years without seizures, the recurrence rate after drug discontinuation is high; in Lennox-Gastaut syndrome, a longer treatment period may be required. 4. The discontinuation process should be slow and may last for several months or even more than 1 year. Withdrawal of benzodiazepines and phenobarbital may result in withdrawal syndrome (anxiety, panic, restlessness, sweating, etc.) in addition to the risk of reoccurrence, so the discontinuation process should be even slower. 5. Patients on multi-drug combination therapy should only be able to reduce one drug at a time, and after withdrawing one drug, there should be at least a 1-month interval, and then withdraw the second drug if there are still no seizures. 6. If a seizure occurs during the withdrawal process, the withdrawal should be stopped and the drug dose should be restored to the pre-seizure dose.