1. Joint pain and pressure pain: Initially, it is mild or moderate intermittent vague pain, which improves at rest and worsens after activity, and the pain is often related to weather changes. In the late stage, there may be persistent pain or nocturnal pain. There is localized pressure pain in the joints, which is especially obvious when accompanied by joint swelling. 2. Joint stiffness: Stiffness and tightness of the joints when waking up in the morning, also known as morning stiffness, can be relieved after activity. Joint stiffness increases when air pressure or air humidity increases, and the duration is usually short, often a few minutes to a few minutes, rarely more than 30 minutes. 3. Enlarged joints: The joints of the hands are obviously enlarged and degenerated, and Heberden’s nodes and Bouchhard’s nodes may appear. Some knee joints may also be enlarged due to bone formation or joint effusion. 4. Bone friction sound (sensation): Due to the destruction of articular cartilage and uneven joint surface, bone friction sound appears when the joint moves, mostly in the knee joint. 5, joint weakness, mobility: joint pain, decreased mobility, muscle atrophy, soft tissue contracture can cause joint weakness, walking leg weakness or joint locking, can not be fully straightened or mobility impairment.