Diabetic nephropathy (DN) is a major microangiopathy in diabetes mellitus, mostly seen in diabetic patients with more than 10 years of disease duration, and end-stage renal failure (ESRD) caused by DN has become one of the major causes of death in diabetic patients. In addition to blood glucose control, symptomatic, supportive, antihypertensive, lipid-lowering and anticoagulant treatments, there are no other effective methods in Western medicine, while Chinese medicine has great advantages in improving clinical symptoms, reducing urine protein and delaying the deterioration of renal function. In addition to the treatment of Yin deficiency and dry heat, Qi and Yin deficiency, and Yin and Yang deficiency, Chinese medicine also treats from the theory of Sanjiao, and has created the theory of Liao disease and the theory of miniature Y obstruction, which have greatly enriched the theory of Chinese medicine treatment of diabetic nephropathy. The combination of traditional Chinese medicine and Western medicine in the treatment of diabetic nephropathy through the combination of disease differentiation and staging and differentiation has also made more and more people see the advantages of traditional Chinese medicine in treating diabetic nephropathy. Chen Ming, Department of Nephrology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine. Diabetic nephropathy is a kidney disorder secondary to diabetes mellitus. Most modern medical practitioners believe that the basic pathological mechanism of the disease is characterized by the deficiency of the origin and the symptoms of the symptoms, which can be summarized as: deficiency of liver and kidney yin, deficiency of both spleen and kidney qi and yin, deficiency of spleen and kidney qi, deficiency of spleen and kidney yang, and deficiency of both yin and yang; and the symptoms of the symptoms are: water-dampness, damp-heat, turbid toxicity, and blood stasis. Professor Qi Luguang [1] believes that the pathogenesis of thirst is based on yin deficiency and dryness and heat as the symptoms, and the main pathogenesis is that the liver, spleen and kidney are damaged due to the complication of kidney disease, and the interconnection of phlegm and blood stasis leads to the disorder of water metabolism. The treatment of proteinuria is persistent and difficult to disappear. The treatment is to benefit the qi, strengthen the spleen, tonify the kidneys, activate the blood and remove blood stasis, and give Kidney Qi Pill with reduction. Professor Ye Rengao [2] divided diabetic nephropathy into five types of deficiency evidence and three types of actual evidence. The five types of deficiency include qi-yin deficiency, liver-kidney yin deficiency, spleen-kidney qi deficiency, spleen-kidney yang deficiency, and yin-yang deficiency; the three types of symptoms include blood stasis, water-dampness, and dampness. Professor Li Xianzhu [3] believed that the basic pathogenesis of diabetic nephropathy is positive deficiency and evil actuality, and the long-standing disease enters the complex. The positive deficiency is dominated by spleen-kidney qi deficiency and liver-kidney yin deficiency; the evil reality is dominated by phlegm and blood stasis blocking the kidney ligaments, and he created his own formula for the treatment of diabetic nephropathy, with remarkable results. The pathogenesis of diabetic nephropathy is a dynamic process of development, the early stage of deficiency of qi and yin, spleen and kidney deficiency, with the development of the disease, the emergence of water and dampness, turbidity and toxicity, damp heat, blood stasis and other pathological products, and over time, blood stasis blocking the ligaments, water and dampness does not transform, phlegm and turbidity within, mixed with the real, the disease is entangled. Western medicine has divided diabetic nephropathy into five stages according to the characteristics of each stage of the disease. Most doctors divide diabetic nephropathy into three stages: early diabetic stage (equivalent to M’s stage I and II), middle diabetic stage (M’s stage III and IV) and late diabetic stage (M’s stage V). The early stage of diabetic nephropathy is mostly identified as Qi-Yin deficiency, Liver-Kidney Yin deficiency, Yin deficiency and dry heat; the middle stage of diabetic nephropathy is mostly identified as Spleen-Kidney Yang deficiency, Spleen-Kidney Qi-Yin deficiency, Spleen-Kidney Qi-Yang deficiency, water-dampness retention and water-stasis interconnection; the late stage of diabetic nephropathy is mostly identified as Spleen-Kidney Yin-Yang deficiency, Heart-Kidney Yang deficiency, water-dampness, damp-heat, turbid toxicity and water-stasis internal offense. Professor Yu Shijia [4] summarized that the early diabetic nephropathy is either purely qi-yin deficiency type or concurrently blood stasis type or dampness turbidity type. The treatment for the qi-yin deficiency type is to benefit qi and nourish yin, tonify the kidney and consolidate essence; the treatment for the concurrent blood stasis type is to benefit qi and nourish yin, invigorate blood and remove stasis; the treatment for the concurrent dampness turbidity type is to first lightly percolate dampness to eliminate evil, and then tonify the kidney and benefit qi to consolidate the root. Professor Shao Chaodi [5] identified diabetic nephropathy stage IV as the evidence of spleen and kidney qi deficiency, blood stasis and water stagnation, and formulated “Qilian Ling Decongesting Soup” with an addition to tonify the kidney and strengthen the spleen, benefit qi and activate blood, and move water to eliminate swelling. Director Ye Jinghua [6] believed that the onset of diabetic nephropathy is caused by deficiency of the spleen and kidney and stasis of blood, and treatment is based on a combination of staging and typing: 1) early stage of DN: clinical deficiency of liver and kidney yin and deficiency of both qi and yin; 2) middle stage of DN: clinical deficiency of both spleen and kidney qi and yin and deficiency of both spleen and kidney qi and yang; 3) late stage of DN: clinical deficiency of both spleen and kidney yin and yang. Professor Zhang Qi [7] divided diabetic nephropathy into three main types and three concurrent evidence. The three main types include 1) deficiency of both qi and yin: mostly seen in the early stage of DN, the main treatment is to benefit qi and nourish yin, and the formula is Gui Shao Liu Jun Zi Tang with addition and subtraction; 2) deficiency of both spleen and kidney: mostly seen in the clinical stage of DN and those with extreme physical weakness, the treatment is to strengthen both spleen and kidney, and the formula is to add flavor to Ba Wei Ren Qi Wan; 3) deficiency of spleen and kidney: mostly seen in the late stage of DN, the kidney function is obviously damaged, and the serum creatinine and urea nitrogen continue to not fall, and it is appropriate to strengthen the spleen and tonify the kidney to strengthen the root. The formula uses Ginseng and Astragalus Dihuang Tang with extra flavor. The three concurrent symptoms include 1) blood stasis: the treatment is to activate blood circulation and remove blood stasis, but it differs according to the identification of qi stagnation and blood stasis, qi deficiency and blood stasis, yang deficiency and blood stasis, and dampness and toxicity, stasis and blood blockage; 2) dampness and turbidity: cold and dampness are stopped with the method of warming the middle and dispersing cold and removing dampness, spleen and dampness and stomach heat, dampness and heat are intertwined in the middle jiao with the method of nourishing yin and clearing heat and removing dampness, spleen and kidney deficiency and dampness and heat, and it is advisable to strengthen the spleen and consolidate the body, tonify the kidney and fix the essence, clear heat and dampness, and use both tonics and clearing and tonics; 3) late DN Common dampness and turbidity (toxicity) and blood stasis and congestion: the emergency is to treat the symptoms and make the condition stable. If dampness and turbidity become toxic for a long time, and dampness and toxicity turn into heat and rebellion, the treatment should be aromatization of dampness and turbidity, bitter-cold drainage. Professor Yang Nizhi [8] divided diabetic nephropathy into four types, corresponding to the four stages of diabetic nephropathy. 1) dry heat and yin deficiency type: mostly seen in stage I of diabetic nephropathy, treatment: nourishing yin, clearing heat and moistening dryness, prescription: Bai Hu Ren Shen Tang with addition; 2) qi and yin deficiency type: corresponding to the early diabetic stage, i.e., the stage of microproteinuria, treatment: benefiting qi and nourishing yin, prescription: Sheng Wei San combined with Liu Wei Di Huang Tang with addition and reduction. 3) spleen and kidney qi (yang) deficiency type: mostly seen in the early diabetic stage, i.e., the stage of microproteinuria. (Yang) deficiency type: mostly seen in clinical diabetic nephropathy, i.e., the persistent proteinuria stage. Treatment: Strengthening the spleen, warming the kidney, and relieving dampness; prescription: Jin Kui Kidney Qi Pill with addition and reduction; 4) Yang failure, turbidity and toxic stasis: this type is equivalent to the end stage of diabetic nephropathy, that is, the uremic phase. Treatment: Nourish the kidneys to help Yang, lower turbidity and eliminate stasis. The formula: Zhen Wu Tang combined with Er Chen Tang, plus or minus. Professor Dai Xiwen [9] summarized the characteristics of each stage of diabetic nephropathy and concluded that early diabetic nephropathy is mainly due to damage of the five organs and poisoning of the kidney channels; middle and late diabetic nephropathy is due to prolonged disease, poor blood flow and stasis of the kidney channels; spleen and kidney deficiency, failure of qi to transform water, water retention and internal stagnation of dampness; late diabetic nephropathy is mainly due to impaired qi-transformation function of the three jiao and internal obstruction of dampness and toxicity. Sun Jianxin [10] considered that the main pathogenesis of diabetic nephropathy is the blockage of the three jiao qi, water channels and blood channels, and established the treatment method of “unblocking the three jiao, operating the central mechanism, activating blood and water, nourishing yin and tonifying the kidney”. “(Chai Hu 15 g, Baicalin 10 g, Radix Codonopsis 15 g, Radix Panax notoginseng 10 g, Radix Paeoniae Alba 10 g, Radix et Rhizoma Ligustici 10 g, Radix Angelicae Sinensis 10 g, Poria and Poria 10 g each, Radix Cinnamomum 3 g, Rhizoma Atractylodis Macrocephalae 10 g, Rhizoma Zedoariae 10 g, Cornu Cervi Pantotrichum 10 g, Rhizoma Yam 10 g, Dampi 10 g, 3 slices of ginger, 3 g of licorice, 3 jujubes). Zeng Sheng [11] et al. considered that diabetic nephropathy is a symptom of thirst at a certain stage of development, and its identification is similar to the three jiao identification of thirst, while the lower jiao lesions are the main ones: 1) upper jiao lesions are mostly due to heat burning in the lung and stomach, depleting qi and yin, and the formula is Bai Hu plus Ginseng Tang with addition and subtraction; 2) middle jiao lesions are mostly due to dryness in the intestines and internal Qi, and the formula is Zengyi Cheng Qi Tang with addition and subtraction; 3) lower jiao lesions are mostly due to deficiency of both yin and yang, and the formula is Jin Gui Kidney Qi Wan with addition and subtraction. Plus or minus. Ren Aihua et al [12] considered that the basic pathogenesis of DN is the dysfunction of the three jiao, and followed the three jiao theory to treat DN in stages: (1) early treatment focuses on the upper jiao, it is advisable to warm the heart yang and benefit the lung qi, and the formula uses Ling Gui Zhu Gan Tang combined with Sheng Wei Yin and Gan Cao Gan Jiang Tang; ( 2) clinical D N stage treatment focuses on the middle jiao, it is advisable to warm the spleen yang and benefit the middle qi, and the formula uses Wen Shen Tang and Reason Zhong Tang plus or minus. (3) The treatment in the stage of renal dysfunction should be to warm the kidney yang and benefit the vital energy, and the formula is based on Zhen Wu Tang combined with Da Teng Yuan Decoction. Wu Yiling [13] put forward the theory of “the doctrine of luo pathology” and believed that diabetic nephropathy is a kidney luo pathology, in which the evil qi stays in the luo veins, the luo veins are stagnant or blocked, and the stagnant blood and phlegm coalesce and take shape, resulting in the luo resting into accumulation as its main pathological changes. 2) deficiency of both qi and yin and damage to the kidney ligament 3) deficiency of both qi and yang and loss of warmth in the kidney ligament 4) phlegm and turbidity and congestion in the kidney ligament 5) dampness and heat and obstruction of the kidney ligament 6) water and stasis and paralysis of the kidney ligament; 7) phlegm and stasis coalescence and accumulation in the ligament. Professor Nanzheng [14] believed that the basic pathogenesis of diabetic nephropathy is the coexistence of toxicity and deficiency, and the interplay of positive and evil (toxicity), and the core of the pathogenesis is toxicity damage to kidney ligaments. 4. Treatment from the theory of miniature obstruction Lv Renhe [15-16] combined with the theory of “prolonged illness into the ligament” in Chinese medicine, pointed out that DN is essentially a process of prolonged treatment of thirsty disease in Chinese medicine, injuring yin, depleting qi, and interlocking phlegm, heat, stagnation and stasis, forming miniature obstruction, and from obstruction to accumulation, and divided diabetic nephropathy into three stages of treatment: 1) deficiency stage. This is the early stage of diabetic nephropathy, during which the blood vessels do not work and turn into heat, forming “miniature Y obstruction accumulation”, which damages the veins and ligaments very lightly, and should be treated by removing stale qi, relieving anger, clearing heat and invigorating blood; 2) deficiency stage: during this stage, because stale qi is not removed and anger is not relieved, blood flows backwards, forming miniature Y knots, damaging the blood vessels and internal organs, opening the meridians and invigorating blood. Move Qi and Blood. (3) deficiency period: this period is not removed, anger is not resolved, the knot does not dissolve, the accumulation of the masses, long labor does not return to decline, the damaged organs eventually decay, at this time should be preferred to the various treatments of Chinese and Western medicine, in order to improve the quality of life, prolong life.