Omeprazole is a proton pump inhibitor indicated for the treatment of gastric ulcers, duodenal ulcers, stress ulcers, reflux esophagitis and gastrinomas. Omeprazole is a fat-soluble and weakly alkaline drug, which can be specifically distributed in the secretory tubules of the mural cells of the gastric mucosa and converted to the active form of sulfenamide in this highly acidic environment, and then irreversibly binds to the sulfhydryl group of H+-K+-ATPase in the secretory membrane of the mural cells through disulfide bonding, which can inhibit the activity of the enzyme and block the secretion of gastric acid, thus inhibiting the gastric acid secretion. Adverse reactions such as diarrhea, headache, nausea, abdominal pain, gastrointestinal flatulence, increased serum aminotransferase, rash, dizziness, drowsiness, insomnia, etc. may occur after use, which usually disappear spontaneously. Hepatic and renal insufficiency, lactating women should be cautious, allergic to the product, severe renal insufficiency and infants, pregnant women are prohibited. Patients who want to use Omeprazole are advised to go to a regular hospital, consult a professional doctor, cooperate with the doctor to complete the relevant examination, to clarify the cause, and avoid blind use of drugs.