High glycan antigen 199 (CA199) may be due to inflammation, normal physiological phenomena and malignant tumors, etc., which require timely improvement of CT, pathological tissue biopsy and so on. 1. Inflammation: the typical cases are chronic viral infections, cholecystitis, pancreatitis, etc., but they usually show mild elevation, which will not be more than three times of the normal range. 2. Normal physiological phenomenon: when women are in menstruation or breastfeeding, the human body will also secrete a small amount of glycan antigen 199, which will cause the index to rise, and then naturally return to the normal range. 3. Malignant tumors: If Glycoantigen 199 is significantly elevated and accompanied by continuous elevation, especially after exceeding 10 times of the normal range, it is necessary to consider that it is caused by malignant tumors, such as gastric cancer, pancreatic cancer, colon cancer, and so on. The cause of high GLA is complex, and it is necessary to actively carry out other tests to effectively confirm the diagnosis, and take targeted treatment for the cause of the disease.