There are many treatment methods available for colon cancer without surgery, including chemotherapy, molecular targeted drug therapy or traditional Chinese medicine therapy, etc. 1. Chemotherapy: chemotherapy refers to oral chemotherapy drugs and injection chemotherapy drugs. There are many chemotherapy programs, and the commonly used one is capecitabine combined with oxaliplatin. Usually, patients with middle and late stage colon cancer should have at least 12 times of chemotherapy. However, this also needs to be decided in combination with the specific treatment situation and therapeutic effect of patients. 2. Molecular targeted therapy: Targeted therapy is a blocking agent chosen for the tumor to inhibit the growth, proliferation and metastasis of the tumor. Patients with advanced intestinal cancer can use targeted drug therapy under doctor’s guidance if there is no contraindication to the use of targeted drugs, such as bevacizumab, regorafenib, irinotecan and so on. 3. Traditional Chinese medicine treatment: according to the patient’s condition, which varies from patient to patient, in the middle and late stage of colon cancer, Sijunzi Tang and Siwu Tang can be used appropriately to replenish the patient’s qi and blood. It is suggested that patients should consult doctor for examination in time and choose appropriate treatment under doctor’s guidance.