Many outpatients request glucosamine sulfate for the treatment of osteoarthritis, bone spur formation, and osteophytes, mainly because the old American Guidelines for the Treatment of Osteoarthritis of the Joints had previously recommended glucosamine sulfate for patients with osteoarthritis, and some articles reported that it had some therapeutic effect. However, studies in recent years with large samples have found that glucosamine sulfate is not significantly effective in the treatment of osteoarthritis, nor does it have an effect on cartilage repair, and its effect is only equivalent to that of a placebo. Therefore, the latest guidelines no longer recommend the use of glucosamine sulfate for the treatment of osteoarthritis. It is recommended that medical practitioners and patients adjust their treatment strategies to avoid unnecessary waste of medical resources and ineffective treatment. The new treatment guidelines are as follows: I. Guidelines for the treatment of osteoarthritis of the knee (except knee replacement) in the United States 1. Patients with a body mass index (weight/height squared) of more than 25 should lose at least 5% of their body weight 2. In addition, topical NSAIDs, or oral gastroprotective agents and COX-2 inhibitors can be used for patients at high risk of gastrointestinal distress. Intra-articular glucocorticoid injections can be used for short-term pain relief. 5. Arthroscopic surgery can be performed in cases of meniscal injury or free body. 6. Patellar support bands for short-term pain relief. 2. The following therapeutic measures are not recommended in this guideline for the treatment of knee OA 1. joint irrigation 2. glucosamine or (and) chondroitin sulfate 3. foot orthopedic brace 4. in the absence of free body or meniscal Arthroscopic irrigation in the absence of free body or meniscus damage is an indeterminate outcome. 3. Treatment of unspecified therapeutic measures 1. Intra-articular sodium hyaluronate injection for mild and moderate OA 2. Bracing 3. Acupuncture
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