Lazoles are mainly proton pump inhibitors, which can reduce gastric acid secretion by inhibiting adenosine triphosphatase in order to inhibit gastric acid secretion, protect gastric mucosa and anti-H. pylori infection. Mainly divided into three generations, although all are drugs to inhibit stomach acid, but the role and effect of different: 1, the first generation of proton pump inhibitors: such as omeprazole, with a certain degree of inhibition of gastric acid secretion, can relieve acid reflux, heartburn feeling, and side effects are usually small. It is mainly used for patients with peptic ulcer, stress ulcer and reflux esophagitis. However, it is prone to drug interactions with other drugs due to the characteristics of drug metabolism. It is suitable for patients whose acid suppression requirements are not very high and whose combined medications are less; 2. Second-generation proton pump inhibitors: such as lansoprazole, which has a slightly stronger effect on inhibiting gastric acid secretion, improves the patient’s tolerance, and is able to improve symptoms such as indigestion and prolong the secretion of gastric acid. However, patients need to be aware that they should swallow the whole tablet when taking the drug. The safety is better and the drug interaction is smaller; 3. Third generation proton pump inhibitors: such as rabeprazole, which has good acid suppressing effect and is mainly used to treat gastric ulcer, duodenal ulcer, reflux esophagitis, gastrinoma and other diseases. If used in combination with amoxicillin, metronidazole tablets, bismuth potassium citrate and other drugs, it can be used to treat Helicobacter pylori infection. Long-term use of lazoloid drugs to inhibit gastric acid secretion may lead to impaired gastric mucosal function, gastric mucosal atrophy, cause B-vitamin deficiency, megaloblastic anemia or iron deficiency anemia, and even risk of cancer. Therefore, when using drugs, it is important to stop using them in time after achieving the therapeutic purpose and to take them regularly and correctly under the guidance of a physician.