Ms. Zhang, 33 years old, was found to be positive for H. pylori during her physical examination, and then went to the Gastroenterology Clinic and insisted on an injection of antibiotic treatment. Doctors asked about her condition and found that Ms. Zhang did not have any stomach discomfort, but only because she was worried that H. pylori would lead to stomach cancer, so she asked for sterilization treatment, and as a result, she suffered from anxiety and insomnia. With the improvement of living standards, people pay more and more attention to health, and many people will have a physical examination every year. Now the physical examination program have Helicobacter pylori (HP) test this one, many positive results of the crowd even if there is no stomach discomfort, but because of the fear of stomach cancer, and take the report to the hospital gastroenterology department to ask for sterilization treatment, and even some people will be injected with a large number of antibiotics treatment. Is H. pylori really so terrible? Do we need to talk about “bacteria” color change? Is it necessary to kill H. pylori? Therefore, there is no need to be overly nervous if you test positive for H. pylori, and most people do not need to undergo sterilization treatment. Of course, H. pylori will increase the risk of gastric cancer, peptic ulcer and gastric lymphoma, so the H. pylori positive people should be moderately vigilant, once there is epigastric pain, abdominal distension, acid reflux belching, heartburn, nausea and vomiting, vomiting of blood and black stools, etc., you should promptly undergo gastroscopy, according to the results of the sterilization and appropriate treatment. Sterilization is recommended only in the following cases: 1, peptic ulcer; 2, chronic gastritis with obvious abnormalities (gastric mucosa with erosions, moderate to severe atrophy and intestinal epithelial hyperplasia); 3, family history of gastric cancer; 4, associated with erosive duodenitis; 5, symptoms of dyspepsia, poor efficacy of conventional treatment. To kill Helicobacter pylori, it is recommended to take medication under the guidance of gastroenterologists, regular, adequate amount, full course of medication, prepared by the Chinese Medical Association, Division of Gastroenterology, Helicobacter pylori and peptic ulcer group, “The Fifth National Helicobacter pylori Infection Treatment Consensus Report” is an authoritative guide to treating Helicobacter pylori in our country, which recommends how to eliminate the Helicobacter pylori by the guide with a “non-bismuth quadruple program. Non-bismuth quadruple regimen”, that is, PPI (proton pump inhibitor) + amoxicillin + clarithromycin + metronidazole. The non-bismuth quadruple regimen is divided into sequential therapy (PPI + amoxicillin orally for the first 5 or 7 days, and PPI + clarithromycin + metronidazole orally for the second 5 or 7 days), concomitant therapy (4 medications taken simultaneously for 10 or 14 days), and mixed therapy (the same as sequential therapy for the first 5 or 7 days, and concomitant therapy for the second 5 or 7 days), depending on the method of drug administration. Some patients abused the drugs not only did not kill H. pylori but also led to drug resistance, which caused some difficulties for doctors to treat them.