Loratadine and Valium should not be taken together because loratadine belongs to the third generation of anti-allergic drugs, mainly used to treat some skin allergic diseases. Therefore, loratadine and Valium should not be used together. In addition to Valium, loratadine should not be taken together with clonazepam and alprazolam. It is also not recommended to drink alcohol or beverages containing alcohol when using loratadine.