Stage II colon cancer should choose different chemotherapy regimens according to different situations. 1. If accompanied by high-risk factors (number of cleared lymph nodes less than 12, nerve invasion, vascular cancer embolism, preoperative obstruction, perforation, positive margins, and poor histological differentiation (excluding high instability of microsatellites), adjuvant chemotherapy is recommended. 2. Single high-risk factor: single oral capecitabine is recommended, usually for six months. 3. Combination of multiple high-risk factors: It is recommended to apply the combination chemotherapy program FOLFOX (oxaliplatin + calcium folinate + fluorouracil). The purpose of the above chemotherapy program is to prolong the survival time of patients, improve pain, and improve the quality of life. If diagnosed with stage II colon cancer, one should actively seek medical treatment and standardize the treatment under doctor’s guidance to improve the disease prognosis.