Bone metastasis of liver cancer is a manifestation of cancer development to middle or late stage, but it is impossible to deduce how long it can last, and it needs to be judged with the related treatment of patients, such as radiotherapy, chemotherapy and other therapeutic effects. Liver cancer is a malignant tumor disease of liver, which can be classified into early, middle and late stages according to the degree of development of the disease, and when distant metastasis such as bone metastasis occurs in middle and late stages of liver cancer, the survival rate of five years is relatively low. However, it depends on the patient’s treatment effect and disease control to determine how long the survival period of liver cancer with bone metastasis is. If the development of cancer can be effectively suppressed, the survival period will be longer, while if the cancer cells grow rapidly, the survival period will be shorter. Patients with advanced liver cancer should actively receive treatment. Even if regular medical treatment cannot effectively cure the cancer, it can still help patients alleviate the pain and improve the quality of life in advanced stage.