The growth of a grain like a grape and a little itchy at the vaginal opening may be caused by eczema, warts, genital herpes and other factors. 1. Eczema: it may be related to abnormal immune function, weaker skin barrier function and other factors, which can lead to eczema in the vaginal opening area, which gradually becomes herpes or blisters, and may be accompanied by intense itching, burning pain and other symptoms. 2. Condyloma acuminatum: a sexually transmitted disease, usually caused by human papillomavirus infection, which can cause small particles to appear in the vaginal area, and the area will gradually increase, accompanied by mild itching and pain. 3. Genital herpes: usually caused by herpes simplex virus infection, related to unclean sex, can make small herpes appear in the vaginal opening, similar to grapes, may be accompanied by pain, itching and other symptoms. The vaginal opening grows a grain of like grapes also a little itchy, it is recommended to seek medical treatment for appropriate examination and treatment, to avoid aggravation of the lesion.