CDKL5 is short for cell cycle protein-dependent protein kinase 5 and is located on the X chromosome. Mutations in this gene can lead to abnormalities in the encoded protein and can cause a variety of neurological disorders, collectively known as CDKL5 syndromes. It is a disorder that can cause seizures, growth retardation, autism, hypotonia, anorexia, scoliosis, feeding difficulties, hand loss, speech delay, and other clinical manifestations. Because of the X-chromosome dominant inheritance, it is predominantly a female disorder, and there is no specific treatment available for this disorder.