Lymphopenia is mainly seen in the application of adrenocorticotropic hormones, alkylating agents and radiation injury, immunodeficiency disorders, hematologic disorders, or the acute phase of certain infectious diseases. Normal people can have low lymphocytes under stress.
1. Adrenocorticotropic hormone can interfere with the glucose metabolism of lymphocytes, causing lymphocyte cytoplasmic degeneration, cytosolic decomposition, reduced lymphocyte proliferation and increased apoptosis, resulting in a decrease in the number of lymphocytes.
2. Radiation and high-dose alkylating agents (cytarabine) can interfere with the double-stranded DNA structure of lymphocytes, causing lymphocyte apoptosis.
3. Acquired Immunodeficiency Disease (AID) is a human immunodeficiency virus (HIV) infectious disease that causes a progressive decrease in the number of T-lymphocytes.
4. Blood system diseases, such as aplastic anemia and acute myeloid leukemia, can also lead to low lymphocyte count.
5. Lymphocytopenia can occur in normal people under stress such as stimulation and severe psychological trauma.
Reduced lymphocytes will affect the body’s immune function, causing secondary infections of various microorganisms and the occurrence of tumors. Therefore, low lymphocyte counts should be reviewed in a timely manner, and if they continue to decrease, the cause should be investigated. Specific diagnosis and treatment should be carried out under the guidance of a physician.