When faced with a skull defect, patients must undergo cranial bone repair surgery to ensure that our intracranial brain tissue is in a normal state, which is a matter of our health and life. When it comes to cranial repair surgery, many patients inevitably play a small role in their minds about the cost of cranial repair surgery. Cranial repair surgery differs from other surgeries in that the cost of the surgical material accounts for the greater part of the overall cost that is, the settlement cost may vary greatly when different cranial repair materials are chosen. Like traditional titanium mesh material, the overall price is not high. It was quite a good material for cranial bone repair in the past. In clinical applications, many patients are perennially plagued by complications associated with titanium mesh bone plates. For example, titanium mesh is a metallic material that is not insulated, which can lead to postoperative sensitivity to hot and cold reactions; covered repair, titanium mesh edges can cause cutting injuries to the scalp and produce pain, etc.; in addition, this material can also interfere with CT MRI and other examinations, and the shaping effect is not good. The relatively expensive PEEK material, on the other hand, has obvious advantages in clinical applications. The properties of polymeric biomaterials that specifically mimic human bone research have a high degree of compatibility with autologous cranial bone. With the support of three-dimensional reconstruction technology, PEEK bone plates can be seamlessly embedded in the defective bone window, blending in with the autologous cranial bone. The advantages are obvious in terms of aesthetics, stiffness, and stability. The cost of cranial bone repair surgery depends on the patient’s choice. Patients are advised to consider the surgical material carefully.