Malignant tumors that disappear on their own There are always miraculous things that happen in life, and certainly in medicine, such as malignant tumors that disappear on their own; it is worth mentioning that although rare, cancer does disappear on its own. The Japanese National Cancer Center reported a case of a 64-year-old colon cancer patient whose cancer regressed on its own: the old man went to the local hospital for “blood in the stool” and the colonoscopy showed a typical colon cancer lesion with a diameter of 30 mm, and the pathological biopsy result was a moderately differentiated tubular adenocarcinoma. Three weeks later, the patient was transferred to the National Cancer Center Hospital, where another colonoscopy was performed and the cancerous lesion was found to be 20 mm smaller than the previous examination, with the same pathological findings. According to the TNM staging method, the diagnosis was stage I colon cancer (T2N0M0). While doing the surgery, something happened that made the doctors’ jaws drop: the cancerous lesion disappeared from the excised colon segment! Only a discolored scar was left in the corresponding area. The doctors looked everywhere for cancer cells on the fixed specimen sections and found only a bunch of inflammatory lymphocytes, plasma cells, and fibrosis between the submucosa and the lamina propria. Postoperatively, colonoscopy was repeated again, and this time no tumor was found in the colon and rectal segments, so the discharge diagnosis was: colon cancer regressed on its own. The patient had no symptoms of cancer recurrence 1 year after surgery. Spontaneous Regression of Cancer was first introduced by Dr. Stewart in New York, and refers to the partial or complete disappearance of a malignant lesion when no treatment is received or when the treatment received is deemed insufficient to produce a curative effect. Worldwide, self-resolution of primary or metastatic tumors that are biopsy-confirmed malignant has occurred in many cases of cancer, including colon and breast cancer: however, self-resolution is very rare in the large cancer population, occurring in only 1 in 60,000-100,000 cancer patients (exact data are difficult to count). Self-regression of hepatocellular carcinoma has been reported in 70 cases, while colon cancer has been reported in only 14 cases between 1900 and 2005. It has been analyzed that the presence of prolonged hyperthermia due to severe sepsis may be a key factor in some cases, triggering a hyperimmune response in the organism. In other cases, psychological stress reactions, perioperative stress reactions to surgery at other sites, and even religious rituals have been included by scholars in the analysis of causes. However, the mechanism of occurrence of this rare condition cannot be elaborated yet because of the extremely low incidence and the difficulty to further study cases that occur one after another. It is worth mentioning that, although rare, the phenomenon of self-resolution of cancer does exist. Therefore, if a “prophet” holds the patient’s hand or a “miracle doctor” sells a “miracle medicine” to the patient, then a “miracle” is born. “miracle” is born …… Instead of worshiping the “prophet” and “miracle medicine” or expecting to be the lucky one in 100,000. The first one in 100,000 is the lucky one, but it is better to give your body to the accurate and proven medicine.