Which material to use for skull repair is a question that patients with cranial defects are eager to understand. The commonly used material on the market is titanium mesh, which is also called synthetic titanium mesh. Although this material is widely used and is more advanced than some other traditional materials, it is not the ideal repair material for skull defects. Because titanium mesh is a metallic material, patients are prone to sensitivity to hot and cold stimulation after surgery, fluid is easily generated or stored in the subcutaneous tissues to be easily infected, and local discomfort or chronic pain may occur in the lesion. For example, the appearance of special areas such as temporal fossa and brow frame is not good after repair. If the repair is done with metal titanium plate, there may be radiofrequency effect when doing MRI, it will localize fever or burn the surrounding tissues. Titanium mesh is sensitive to heat and cold after cranial repair, with chronic local pain and more subcutaneous fluid; after repair, it affects patients to receive CT, MRI and other medical examinations; chronic cutting ulcers, stress perforation cause cranial repair failure; irregular facial and cranial parts such as temporal fossa, zygomatic arch, brow frame, etc. have poor cosmetic appearance after repair, etc. Today there are no side effects of cranial repair is now the new PEEK material, compared to conventional repair materials have made great progress, PEEK material is a bionic bone, according to the degree of cranial defects can be three-dimensional customization, accurate implantation of the defect area, is a good choice of material for patients with cranial defects.