Premature rupture of membranes at 20 weeks has a low chance of preserving the fetus, but it is something that needs to be treated promptly. Preterm rupture of membranes is a natural rupture of membranes that occurs before labor, mostly due to reproductive tract infections, such as anaerobic bacteria, group B streptococcus, etc. If the preterm rupture of membranes occurs at a younger gestational week, the survival rate of the fetus is worse, and the risk of maternal infection will also increase. Therefore, if the fetus occurs premature rupture of membranes, it is necessary to consult a doctor in a timely manner, and choose the way to deal with under the doctor’s advice. During pregnancy, it is important to strengthen hygiene education and guidance, active prevention and treatment of reproductive tract infections. At the same time, it is necessary to avoid a sudden increase in abdominal pressure, supplementation with adequate amounts of vitamins, calcium, copper and zinc and other nutrients.