The side effects of targeted drugs for liver cancer include gastrointestinal side effects, hand-foot syndrome, hypertension, skin side effects, bleeding and so on. Targeted drug therapy is one of the important treatments for advanced liver cancer, and the following side effects are often caused by the use of drugs. 1. Gastrointestinal side effects, such as diarrhea, decreased appetite, nausea, vomiting and abdominal pain. 2. Hand-foot syndrome clinically, mainly in the hands and feet skin flaking, ulcers, pain, redness and swelling and other changes. 3. After the use of drugs, some patients will have elevated blood pressure, taking valsartan and other antihypertensive drugs for treatment, for patients whose blood pressure is difficult to control, targeted drugs need to be reduced or discontinued. 4. The drug will also have skin side effects, clinical symptoms such as rash and itching. 5. Bleeding side effects are rare, such as hematuria and nosebleeds. It is recommended to go to the regular hospital to assess the condition, follow the doctor’s instructions to cooperate with the treatment, choose the appropriate treatment program, so as not to delay the condition. Please strictly follow the doctor’s instructions for medication, do not self-medicate.