Drug-associated osteomyelitis is a new disease that has occurred in the last 20-30 years, and the reason for its occurrence is mainly related to drugs, which are mainly of two major types, one is anti-osteoclast drugs, and the other is anti-angiogenic drugs. The most common is similar to zoledronic acid, this kind of drugs and osteoclasts after the combination of the bone metabolism occurs a kind of stagnant state, no vitality of the bone is very easy to be injured and difficult to heal, which is the occurrence of jawbone drug-related osteomyelitis is generally accepted as the pathogenesis. However, with the deepening of research and clinical understanding, it has been found that these drugs are toxic not only to bone, but also to soft tissues. Therefore, these drugs can be toxic to bone, as well as to the gingiva and mucous membranes, which affects the healing process, and this is the main etiologic mechanism.