High thyrotropin in infants is usually combined with clinical evidence of hypothyroidism. In neonates, thyrotropin generally does not exceed 10 mU/L, and thyroid hormone replacement is not considered within 10 mU/L. Children with high thyroid stimulating hormone should be followed up regularly. If the thyroid stimulating hormone is high only once, it can be rechecked after 1 month, and after the recheck, if it is high twice in a row and higher than once, it can be treated with euglycemic therapy. In addition, children with high TSH alone should not only be retested, but also checked for thyroid hormone pentathlon.