Transparent small bubbles on children’s hands may be caused by hand, foot and mouth disease, herpes simplex, herpes sweating and other diseases, which can be treated with appropriate drugs according to different diseases. 1. Hand, foot and mouth disease: a viral skin disease characterized by blisters occurring on the hands, feet and mouth, mostly in children. Patients should be isolated to prevent contagion, and topical glycerin lotion can be used on the lesions. 2. Herpes simplex: caused by herpes simplex virus (HSV), clinically characterized by clustered blisters, self-limiting, but prone to recurrence, can be used externally with antiviral drugs, such as 3% acyclovir ointment, 1% penciclovir cream or glycerine lotion. 3. Sweat herpes: a special type of hand eczema, can be used externally with glucocorticosteroids such as Dinaid cream, severe itching can be oral antihistamines such as cetirizine. Children’s hands with transparent bubbles may have other reasons, parents should be brought to the hospital in time to seek medical attention, under the guidance of specialists in medicine, so as not to delay the condition.