Urine amylase 600 is not a contraindication for gallbladder stone surgery and can be performed. Contraindications for gallbladder stones are purulent cholangitis, combined acute pancreatitis, severe cirrhosis, and associated severe bleeding disorders. In addition, surgery is preferred when accompanied by clinical symptoms or complications. It is also an indication for surgery when the number of stones is large and the diameter is ≥2 to 3 cm. Urinary amylase 600 U/L may be caused by a variety of factors. If there are no symptoms of pancreatitis, surgical treatment may be performed first, and if necessary, choledochotomy may be performed to see if there is any biliary obstruction. Specifically should go to the hospital, under the guidance of the doctor to choose the appropriate way of treatment.