TPF regimen mainly refers to three kinds of drugs: cisplatin, doxorubicin and fluorouracil, which are commonly used as induction chemotherapy regimen before radiotherapy or metastatic nasopharyngeal cancer treatment regimen for nasopharyngeal cancer. Chemotherapy mainly kills cancer cells through chemicals, and is a systemic form of chemical drug treatment. In the TPLF regimen, cisplatin, mainly in the form of a hydrated cation, binds to intracellular DNA to form interstrand, intrastrand, or protein-DNA cross-links, thereby disrupting the structure and function of DNA. Doxorubicin can enhance the polymerization of microtubule proteins, thereby disrupting the mitosis of tumor cells to achieve a good anti-tumor effect. Fluorouracil can inhibit thymine nucleotide synthetase, belonging to the antimetabolic antitumor drugs, to block the conversion of deoxypyrimidine nucleotides into thymine nucleotides, interfering with DNA synthesis of tumor cells, inhibiting the growth of tumors. The combined use of these three drugs can play a good anti-tumor effect in nasopharyngeal carcinoma chemotherapy and improve the survival rate of nasopharyngeal carcinoma patients, it should be noted that, allergic to the above drugs are prohibited, and the drugs need to be applied under the guidance of doctors.