Substantial bladder wall mass is not necessarily cancer, but may also be related to other factors such as cystitis, bladder polyps and benign tumors. 1. Bladder cancer: it can lead to the appearance of a substantial mass in the affected area, and patients may also have symptoms such as hematuria at the same time. 2. Cystitis: especially chronic cystitis, under the repeated stimulation of inflammation, it can lead to local tissue proliferation in the bladder wall, and then a substantial mass will appear. 3. Bladder polyps: can also lead to the appearance of a substantial mass in the affected area, and usually, the patient does not have other uncomfortable symptoms. 4. Benign tumors, such as papillomas, can also lead to the appearance of a substantial mass on the bladder wall. In this case, it is impossible to determine the cause of the disease. It is recommended that patients go to regular hospitals to confirm the diagnosis, and combined with the cause of the targeted treatment, and strive for early recovery.