Metoprolol long-term side effects on the body include chest pain, weight gain, excessive sweating, hair loss, in addition to the circulatory system, nervous system, respiratory system and other aspects. 1. Circulatory system: temporary deterioration of heart failure, prolongation of way conduction time, arrhythmia, fainting and so on. 2. Nervous system: sleep disorders, sensory abnormalities, memory impairment, anxiety, nervousness, etc. 3. Respiratory system: shortness of breath, bronchial asthma or bronchospasm may occur in those with asthma symptoms. 4. Others: elevated transaminases, tinnitus, arthralgia, dry mouth, skin allergic reactions, etc. Metoprolol is mainly used in the clinic for the treatment of hypertension, coronary heart disease, heart failure, hyperthyroidism, cardiac neurosis, etc. It is forbidden to be used in pregnant and lactating women, in addition to patients with cardiogenic shock, sick sinus node syndrome, high degree of atrioventricular conduction block, and acute heart failure can not be applied. The application of this drug in the clinic should be individualized treatment, so it should be carried out under the guidance of professional physicians in regular hospitals.