The difference of aminotransferase between two tests is too big usually need to be checked again after improving the lifestyle and diet, if the result is normal, usually no need to deal with, if it is high, need to be further examined to clarify the cause. Aminotransferases are mainly found in liver cells, and they are one of the basic indicators of liver function tests. The level of transaminases in the serum is usually low and stable. When liver cells are damaged due to late night drinking, overwork, etc. or liver diseases such as hepatitis, cirrhosis, liver cancer, etc., it will lead to the release of transaminases from the liver cells and increase the transaminases. When the difference of transaminases between two checkups is much, patients are usually advised to take another checkup after improving their life style, such as going to bed early and getting up early, quitting smoking and drinking, eating light diet and exercising appropriately, etc. If the checkup result is normal, no special treatment is usually needed, which is usually due to physiological factors, such as staying up late, overwork, alcohol abuse and mental stress. If the test results are high, you can further improve the examination under the guidance of the doctor, such as albumin, bilirubin, alkaline phosphatase, alpha-fetoprotein and other tumor markers, hepatitis B five and other indexes are normal, or ultrasound, CT and other imaging tests, to clarify whether the patient has hepatitis, cirrhosis, liver cysts or tumors and other liver-occupying lesions, in order to carry out targeted treatment. If the difference between the two tests of transaminases is too much, it is recommended that the patient should consult a doctor in time, under the guidance of the doctor for further examination, to clarify the cause of the disease, and actively treat it, so as to avoid delaying the condition.