Endothelial thickening without menstruation may be pregnant, may also be long-term emotional stress, overwork and other physiological factors, there may be abnormal thyroid function and other pathologic factors lead to different reasons for different treatments, should be timely to find out the cause of the doctor’s orders targeted treatment. 1. Physiological factors: (1) pregnancy: if women of childbearing age, recent history of sexual intercourse, no menstruation should first consider the possibility of pregnancy, it is recommended to carry out an early pregnancy test to check whether pregnancy. (2) long-term emotional stress or overwork: easily lead to a decline in the body’s pituitary gonadotropin secretion, causing menstrual disorders, menstrual delay phenomenon. It is recommended to change bad habits, work and rest on time, adjust your emotions and keep a calm mind. 3. Pathological factors: It mainly refers to the abnormal function of thyroid gland, such as hypothyroidism, hyperthyroidism, etc., which affects the normal operation of the endocrine system, resulting in irregular menstruation, delayed menstruation, amenorrhea and so on. You should actively cooperate with your doctor to treat hyperthyroidism, hypothyroidism and other primary diseases. There may be other reasons for not having menstruation due to thickening of the endothelium, so you should consult your doctor in time to find out the reasons and get targeted treatments according to the doctor’s instructions.