Medications that relieve pain relatively quickly in case of toothache include ibuprofen and others. The specific cause should be analyzed and the relevant treatment should be carried out. Toothache is a disease that people often encounter, there are many causes of toothache, may be suffering from pulpitis, periodontal abscess, or wisdom teeth pericoronitis. These cases should be oral antibiotics for anti-inflammatory pain treatment, commonly used antibiotics are cefixime, azithromycin, etc., at the same time with metronidazole together, anti-inflammatory effect is better, if the pain is more serious, oral ibuprofen. In addition to anti-inflammatory pain relief symptomatic treatment of toothache, it is more important to treat the cause. If you are suffering from pulpitis, root canal treatment is recommended. If the pain is caused by periodontal abscess, scaling is recommended, and if severe, incision abscess drainage. If the inflammation is caused by wisdom teeth, removal of the wisdom teeth is recommended after the swelling and pain disappears. Toothache, also need to consider other diseases, drugs need to be rationally applied under the guidance of a physician.