In general, it is not recommended to take medication to prevent chickenpox when exposed to a person with chickenpox, but rather to take vaccination and intramuscular injection of immunoglobulin to prevent the disease. Chickenpox patients are contagious from the time the rash breaks out until the herpes scabs over, and there is a certain risk of infection for susceptible people who do not have antibodies in their bodies. Particularly in immunocompromised individuals, disseminated chickenpox is more likely to occur. Chickenpox infection during pregnancy can lead to fetal malformation, preterm labor, or stillbirth. Chickenpox within a few days before delivery can occur in newborns, who are often critically ill. However, it is not recommended to take medication to prevent chickenpox after exposure to a person with chickenpox, mainly because there is no specific medication for the chickenpox virus at this time. The first thing we need to do after contact is to determine the status of the varicella patient at this time. For patients who have completed respiratory isolation and have all herpes scabs, their infectivity is relatively low, and generally will not cause infection. If the contacted patient is in the onset of disease, we should be vaccinated in time for prophylaxis. However, for immunocompromised or immunosuppressed patients or pregnant women, the efficiency of vaccination is relatively low. If there is a history of patient exposure at this time, intramuscular immunoglobulin or herpes zoster immunoglobulin injections may be an option to prevent or reduce the condition.